With synproxy, the middlebox can be on the server itself

Multipath TCP works by adding the new TCP options defined in RFC 6824 in all TCP segments. A Multipath TCP connection always starts with a SYN segment that contains the MP_CAPABLE option. To use benefit from Multipath TCP, both the clients and the server must be upgraded with an operating system that supports Multipath TCP. With such a kernel on the client and the servers, Multipath TCP should be used for all connections between the two hosts. This is true provided that there are no middleboxes on the path between the client and the server.

A user of the Multipath TCP implementation in the Linux kernel recently reported problems on using Multipath TCP on a server. During the discussion, it appeared that a possible source of problems could be the synproxy module that is part of recent iptables implementations. synproxy, as described in a RedHat blog post can be used to mitigate denial of service attacks on TCP by filtering the SYN segments. This module could be installed by default on your server or could have been enabled by the system administrators. If you plan to use Multipath TCP on the server, you need to disable it because synproxy does not currently support Multipath TCP and will discard the SYN segments that contain the unknown MP_CAPABLE option. In this case, the middlebox that breaks Multipath TCP resides on the Multipath TCP enabled server…